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Cyclophosphamide is an inactive prodrug and is converted to its active metabolite in part by CYP3AThe rate of metabolism and the leukopenic activity of cyclophosphamide are reportedly increased by chronic coadministration of CYP3A4 inducersThere is a potential for increased cyclophosphamide toxicity when coadministered with carbamazepine.
When carbamazepine is given with drugs that can increase or decrease carbamazepine levelsclose monitoring of carbamazepine levels is indicated and dosage adjustment may be required.
Some of these cardiovascular complications have resulted in fatalitiesMyocardial infarction has been associated with other tricyclic compounds.
Clinically meaningful drug interactions have occurred with concomitant medications and includebut are not limited tothe following:
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