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The reports that the concomitant use of Zyloprim and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causationReview of these case reports indicates that the patients were mainly receiving thiazide diuretics for hypertension and that tests to rule out decreased renal function secondary to hypertensive nephropathy were not often performedIn those patients in whom renal insufficiency was documentedhoweverthe recommendation to lower the dose of Zyloprim was not followedAlthough a causal mechanism and a cause-and-effect relationship have not been establishedcurrent evidence suggests that renal function should be monitored in patients on thiazide diuretics and Zyloprim even in the absence of renal failureand dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected.

Call your doctor immediately if you experience any of the following serious side effectsFeversore throatand headache with a severe blisteringpeeling and red skin rash Any sign of skin rashno matter how mild Nauseaupper stomach painitchingloss of appetiteweight lossdark urineclay-colored stoolsjaundice Pain or bleeding when urinating Urinating less frequently or not at all Joint pain or flu symptoms Easy bruisingunusual bleedingor purple or red pinpoint spots under the skin Severe tinglingnumbnesspainor muscle weakness.

Zyloprim is the brand name of the drug allopurinolwhich is used to treat gouthigh levels of uric acid in the bodyoften caused by certain cancers and cancer treatmentsand kidney stones.

Liver functionAllopurinol may reduce liver function and can cause liver failureIf you have liver problemsdiscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is neededYour doctor may want to test your liver function regularly with blood tests while you are taking this medication.

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